Selective antitumor activity of roscovitine in head and neck cancer
Identifieur interne : 000B38 ( Main/Exploration ); précédent : 000B37; suivant : 000B39Selective antitumor activity of roscovitine in head and neck cancer
Auteurs : Cyril Gary [États-Unis] ; Michael Hajek [États-Unis] ; Asel Biktasova [États-Unis, Australie] ; Gary Bellinger [États-Unis] ; Wendell G. Yarbrough [États-Unis] ; Natalia Issaeva [États-Unis]Source :
- Oncotarget [ 1949-2553 ] ; 2016.
Abstract
Radiation and chemotherapy that are commonly used to treat human cancers damage cellular DNA. DNA damage appears to be more toxic to cancer cells than normal cells, most likely due to deregulated checkpoint activation and/or deficiency in DNA repair pathways that are characteristics of many tumors. However, unwanted side effects arise as a result of DNA damage to normal cells during the treatment.
Here, we show that roscovitine, a cyclin-dependent kinase (CDK) inhibitor that inhibits CDK-1, CDK-2, CDK-5, CDK-7, and CDK-9 due to competitive binding to the ATP site on the kinases, causes significant DNA damage followed by p53-dependent cell death in human papilloma virus (HPV)-positive, but not in HPV-negative, head and neck cancer cells. Since HPV positivity was a molecular marker for increased sensitivity of cells to roscovitine, we reasoned that systemic roscovitine administration would not be toxic to healthy HPV-negative tissue. Indeed, low roscovitine doses significantly inhibited the growth of HPV-associated xenografted tumors in mice without causing any detectable side effects.
Given that inhibition of CDKs has been shown to inhibit replication of several viruses, we suggest that roscovitine treatment may represent a selective and safe targeted therapeutic option against HPV-positive head and neck cancer.
Url:
DOI: 10.18632/oncotarget.9560
PubMed: 27233076
PubMed Central: 5122414
Affiliations:
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xml:lang="en" level="a" type="main">Selective antitumor activity of roscovitine in head and neck cancer</title><author><name sortKey="Gary, Cyril" sort="Gary, Cyril" uniqKey="Gary C" first="Cyril" last="Gary">Cyril Gary</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery Division of Otolaryngology, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Surgery Division of Otolaryngology, Yale University, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Hajek, Michael" sort="Hajek, Michael" uniqKey="Hajek M" first="Michael" last="Hajek">Michael Hajek</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery Division of Otolaryngology, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Surgery Division of Otolaryngology, Yale University, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Biktasova, Asel" sort="Biktasova, Asel" uniqKey="Biktasova A" first="Asel" last="Biktasova">Asel Biktasova</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery Division of Otolaryngology, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Surgery Division of Otolaryngology, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4"> Current address: Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Current address: Children's Cancer Institute, Lowy Cancer Research Centre, UNSW</wicri:regionArea><wicri:noRegion>UNSW</wicri:noRegion></affiliation></author><author><name sortKey="Bellinger, Gary" sort="Bellinger, Gary" uniqKey="Bellinger G" first="Gary" last="Bellinger">Gary Bellinger</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery Division of Otolaryngology, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Surgery Division of Otolaryngology, Yale University, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Yarbrough, Wendell G" sort="Yarbrough, Wendell G" uniqKey="Yarbrough W" first="Wendell G." last="Yarbrough">Wendell G. Yarbrough</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery Division of Otolaryngology, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Surgery Division of Otolaryngology, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pathology, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Pathology, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Yale Cancer Center, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Yale Cancer Center, Yale University, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Issaeva, Natalia" sort="Issaeva, Natalia" uniqKey="Issaeva N" first="Natalia" last="Issaeva">Natalia Issaeva</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery Division of Otolaryngology, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Surgery Division of Otolaryngology, Yale University, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Yale Cancer Center, Yale University, New Haven, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea> Department of Yale Cancer Center, Yale University, New Haven</wicri:cityArea></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Radiation and chemotherapy that are commonly used to treat human cancers damage cellular DNA. DNA damage appears to be more toxic to cancer cells than normal cells, most likely due to deregulated checkpoint activation and/or deficiency in DNA repair pathways that are characteristics of many tumors. However, unwanted side effects arise as a result of DNA damage to normal cells during the treatment.</p><p>Here, we show that roscovitine, a cyclin-dependent kinase (CDK) inhibitor that inhibits CDK-1, CDK-2, CDK-5, CDK-7, and CDK-9 due to competitive binding to the ATP site on the kinases, causes significant DNA damage followed by p53-dependent cell death in human papilloma virus (HPV)-positive, but not in HPV-negative, head and neck cancer cells. Since HPV positivity was a molecular marker for increased sensitivity of cells to roscovitine, we reasoned that systemic roscovitine administration would not be toxic to healthy HPV-negative tissue. Indeed, low roscovitine doses significantly inhibited the growth of HPV-associated xenografted tumors in mice without causing any detectable side effects.</p><p>Given that inhibition of CDKs has been shown to inhibit replication of several viruses, we suggest that roscovitine treatment may represent a selective and safe targeted therapeutic option against HPV-positive head and neck cancer.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Westra, Wh" uniqKey="Westra W">WH Westra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaturvedi, Ak" uniqKey="Chaturvedi A">AK Chaturvedi</name></author><author><name sortKey="Anderson, Wf" uniqKey="Anderson W">WF Anderson</name></author><author><name sortKey="Lortet Tieulent, J" uniqKey="Lortet Tieulent J">J Lortet-Tieulent</name></author><author><name sortKey="Curado, Mp" uniqKey="Curado M">MP Curado</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Franceschi, S" uniqKey="Franceschi S">S Franceschi</name></author><author><name sortKey="Rosenberg, Ps" uniqKey="Rosenberg P">PS Rosenberg</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Gillison, Ml" uniqKey="Gillison M">ML Gillison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillison, Ml" uniqKey="Gillison M">ML Gillison</name></author><author><name sortKey="Koch, Wm" uniqKey="Koch W">WM Koch</name></author><author><name sortKey="Capone, Rb" uniqKey="Capone R">RB Capone</name></author><author><name sortKey="Spafford, M" uniqKey="Spafford M">M Spafford</name></author><author><name sortKey="Westra, Wh" uniqKey="Westra W">WH Westra</name></author><author><name sortKey="Wu, L" uniqKey="Wu L">L Wu</name></author><author><name sortKey="Zahurak, Ml" uniqKey="Zahurak M">ML Zahurak</name></author><author><name sortKey="Daniel, Rw" uniqKey="Daniel R">RW Daniel</name></author><author><name sortKey="Viglione, M" uniqKey="Viglione M">M Viglione</name></author><author><name sortKey="Symer, De" uniqKey="Symer D">DE Symer</name></author><author><name sortKey="Shah, Kv" uniqKey="Shah K">KV Shah</name></author><author><name sortKey="Sidransky, D" uniqKey="Sidransky D">D Sidransky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaturvedi, Ak" uniqKey="Chaturvedi A">AK Chaturvedi</name></author><author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name></author><author><name sortKey="Pfeiffer, Rm" uniqKey="Pfeiffer R">RM Pfeiffer</name></author><author><name sortKey="Hernandez, By" uniqKey="Hernandez B">BY Hernandez</name></author><author><name sortKey="Xiao, W" uniqKey="Xiao W">W Xiao</name></author><author><name sortKey="Kim, E" uniqKey="Kim E">E Kim</name></author><author><name sortKey="Jiang, B" uniqKey="Jiang B">B Jiang</name></author><author><name sortKey="Goodman, Mt" uniqKey="Goodman M">MT Goodman</name></author><author><name sortKey="Sibug Saber, M" uniqKey="Sibug Saber M">M Sibug-Saber</name></author><author><name sortKey="Cozen, W" uniqKey="Cozen W">W Cozen</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Lynch, Cf" uniqKey="Lynch C">CF Lynch</name></author><author><name sortKey="Wentzensen, N" uniqKey="Wentzensen N">N Wentzensen</name></author><author><name sortKey="Jordan, Rc" uniqKey="Jordan R">RC Jordan</name></author><author><name sortKey="Altekruse, S" uniqKey="Altekruse S">S Altekruse</name></author><author><name sortKey="Anderson, Wf" uniqKey="Anderson W">WF Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mineta, H" uniqKey="Mineta H">H Mineta</name></author><author><name sortKey="Ogino, T" uniqKey="Ogino T">T Ogino</name></author><author><name sortKey="Amano, Hm" uniqKey="Amano H">HM Amano</name></author><author><name sortKey="Ohkawa, Y" uniqKey="Ohkawa Y">Y Ohkawa</name></author><author><name sortKey="Araki, K" uniqKey="Araki K">K Araki</name></author><author><name sortKey="Takebayashi, S" uniqKey="Takebayashi S">S Takebayashi</name></author><author><name sortKey="Miura, K" uniqKey="Miura K">K Miura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillison, Ml" uniqKey="Gillison M">ML Gillison</name></author><author><name sortKey="D Souza, G" uniqKey="D Souza G">G D'Souza</name></author><author><name sortKey="Westra, W" uniqKey="Westra W">W Westra</name></author><author><name sortKey="Sugar, E" uniqKey="Sugar E">E Sugar</name></author><author><name sortKey="Xiao, W" uniqKey="Xiao W">W Xiao</name></author><author><name sortKey="Begum, S" uniqKey="Begum S">S Begum</name></author><author><name sortKey="Viscidi, R" uniqKey="Viscidi R">R Viscidi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fakhry, C" uniqKey="Fakhry C">C Fakhry</name></author><author><name sortKey="Westra, Wh" uniqKey="Westra W">WH Westra</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Cmelak, A" uniqKey="Cmelak A">A Cmelak</name></author><author><name sortKey="Ridge, Ja" uniqKey="Ridge J">JA Ridge</name></author><author><name sortKey="Pinto, H" uniqKey="Pinto H">H Pinto</name></author><author><name sortKey="Forastiere, A" uniqKey="Forastiere A">A Forastiere</name></author><author><name sortKey="Gillison, Ml" uniqKey="Gillison M">ML Gillison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dayyani, F" uniqKey="Dayyani F">F Dayyani</name></author><author><name sortKey="Etzel, Cj" uniqKey="Etzel C">CJ Etzel</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Ho, Ch" uniqKey="Ho C">CH Ho</name></author><author><name sortKey="Lippman, Sm" uniqKey="Lippman S">SM Lippman</name></author><author><name sortKey="Tsao, As" uniqKey="Tsao A">AS Tsao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ragin, Cc" uniqKey="Ragin C">CC Ragin</name></author><author><name sortKey="Taioli, E" uniqKey="Taioli E">E Taioli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfister, Dg" uniqKey="Pfister D">DG Pfister</name></author><author><name sortKey="Spencer, S" uniqKey="Spencer S">S Spencer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruyere, C" uniqKey="Bruyere C">C Bruyere</name></author><author><name sortKey="Meijer, L" uniqKey="Meijer L">L Meijer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meijer, L" uniqKey="Meijer L">L Meijer</name></author><author><name sortKey="Borgne, A" uniqKey="Borgne A">A Borgne</name></author><author><name sortKey="Mulner, O" uniqKey="Mulner O">O Mulner</name></author><author><name sortKey="Chong, Jp" uniqKey="Chong J">JP Chong</name></author><author><name sortKey="Blow, Jj" uniqKey="Blow J">JJ Blow</name></author><author><name sortKey="Inagaki, N" uniqKey="Inagaki N">N Inagaki</name></author><author><name sortKey="Inagaki, M" uniqKey="Inagaki M">M Inagaki</name></author><author><name sortKey="Delcros, Jg" uniqKey="Delcros J">JG Delcros</name></author><author><name sortKey="Moulinoux, Jp" uniqKey="Moulinoux J">JP Moulinoux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bukanov, No" uniqKey="Bukanov N">NO Bukanov</name></author><author><name sortKey="Smith, La" uniqKey="Smith L">LA Smith</name></author><author><name sortKey="Klinger, Kw" uniqKey="Klinger K">KW Klinger</name></author><author><name sortKey="Ledbetter, Sr" uniqKey="Ledbetter S">SR Ledbetter</name></author><author><name sortKey="Ibraghimov Beskrovnaya, O" uniqKey="Ibraghimov Beskrovnaya O">O Ibraghimov-Beskrovnaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vermeulen, K" uniqKey="Vermeulen K">K Vermeulen</name></author><author><name sortKey="Van Bockstaele, Dr" uniqKey="Van Bockstaele D">DR Van Bockstaele</name></author><author><name sortKey="Berneman, Zn" uniqKey="Berneman Z">ZN Berneman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcclue, Sj" uniqKey="Mcclue S">SJ McClue</name></author><author><name sortKey="Blake, D" uniqKey="Blake D">D Blake</name></author><author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name></author><author><name sortKey="Cowan, A" uniqKey="Cowan A">A Cowan</name></author><author><name sortKey="Cummings, L" uniqKey="Cummings L">L Cummings</name></author><author><name sortKey="Fischer, Pm" uniqKey="Fischer P">PM Fischer</name></author><author><name sortKey="Mackenzie, M" uniqKey="Mackenzie M">M MacKenzie</name></author><author><name sortKey="Melville, J" uniqKey="Melville J">J Melville</name></author><author><name sortKey="Stewart, K" uniqKey="Stewart K">K Stewart</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Zhelev, N" uniqKey="Zhelev N">N Zhelev</name></author><author><name sortKey="Zheleva, D" uniqKey="Zheleva D">D Zheleva</name></author><author><name sortKey="Lane, Dp" uniqKey="Lane D">DP Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yarotskyy, V" uniqKey="Yarotskyy V">V Yarotskyy</name></author><author><name sortKey="Elmslie, Ks" uniqKey="Elmslie K">KS Elmslie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benson, C" uniqKey="Benson C">C Benson</name></author><author><name sortKey="White, J" uniqKey="White J">J White</name></author><author><name sortKey="De Bono, J" uniqKey="De Bono J">J De Bono</name></author><author><name sortKey="O Donnell, A" uniqKey="O Donnell A">A O'Donnell</name></author><author><name sortKey="Raynaud, F" uniqKey="Raynaud F">F Raynaud</name></author><author><name sortKey="Cruickshank, C" uniqKey="Cruickshank C">C Cruickshank</name></author><author><name sortKey="Mcgrath, H" uniqKey="Mcgrath H">H McGrath</name></author><author><name sortKey="Walton, M" uniqKey="Walton M">M Walton</name></author><author><name sortKey="Workman, P" uniqKey="Workman P">P Workman</name></author><author><name sortKey="Kaye, S" uniqKey="Kaye S">S Kaye</name></author><author><name sortKey="Cassidy, J" uniqKey="Cassidy J">J Cassidy</name></author><author><name sortKey="Gianella Borradori, A" uniqKey="Gianella Borradori A">A Gianella-Borradori</name></author><author><name sortKey="Judson, I" uniqKey="Judson I">I Judson</name></author><author><name sortKey="Twelves, C" uniqKey="Twelves C">C Twelves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, C" uniqKey="Cui C">C Cui</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Zhao, M" uniqKey="Zhao M">M Zhao</name></author><author><name sortKey="Peng, S" uniqKey="Peng S">S Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wesierska Gadek, J" uniqKey="Wesierska Gadek J">J Wesierska-Gadek</name></author><author><name sortKey="Wandl, S" uniqKey="Wandl S">S Wandl</name></author><author><name sortKey="Kramer, Mp" uniqKey="Kramer M">MP Kramer</name></author><author><name sortKey="Pickem, C" uniqKey="Pickem C">C Pickem</name></author><author><name sortKey="Krystof, V" uniqKey="Krystof V">V Krystof</name></author><author><name sortKey="Hajek, Sb" uniqKey="Hajek S">SB Hajek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schang, Lm" uniqKey="Schang L">LM Schang</name></author><author><name sortKey="Rosenberg, A" uniqKey="Rosenberg A">A Rosenberg</name></author><author><name sortKey="Schaffer, Pa" uniqKey="Schaffer P">PA Schaffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kotala, V" uniqKey="Kotala V">V Kotala</name></author><author><name sortKey="Uldrijan, S" uniqKey="Uldrijan S">S Uldrijan</name></author><author><name sortKey="Horky, M" uniqKey="Horky M">M Horky</name></author><author><name sortKey="Trbusek, M" uniqKey="Trbusek M">M Trbusek</name></author><author><name sortKey="Strnad, M" uniqKey="Strnad M">M Strnad</name></author><author><name sortKey="Vojtesek, B" uniqKey="Vojtesek B">B Vojtesek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, W" uniqKey="Lu W">W Lu</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y Peng</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tirado, Om" uniqKey="Tirado O">OM Tirado</name></author><author><name sortKey="Mateo Lozano, S" uniqKey="Mateo Lozano S">S Mateo-Lozano</name></author><author><name sortKey="Notario, V" uniqKey="Notario V">V Notario</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Savio, M" uniqKey="Savio M">M Savio</name></author><author><name sortKey="Cerri, M" uniqKey="Cerri M">M Cerri</name></author><author><name sortKey="Cazzalini, O" uniqKey="Cazzalini O">O Cazzalini</name></author><author><name sortKey="Perucca, P" uniqKey="Perucca P">P Perucca</name></author><author><name sortKey="Stivala, La" uniqKey="Stivala L">LA Stivala</name></author><author><name sortKey="Pichierri, P" uniqKey="Pichierri P">P Pichierri</name></author><author><name sortKey="Franchitto, A" uniqKey="Franchitto A">A Franchitto</name></author><author><name sortKey="Meijer, L" uniqKey="Meijer L">L Meijer</name></author><author><name sortKey="Prosperi, E" uniqKey="Prosperi E">E Prosperi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crescenzi, E" uniqKey="Crescenzi E">E Crescenzi</name></author><author><name sortKey="Palumbo, G" uniqKey="Palumbo G">G Palumbo</name></author><author><name sortKey="Brady, Hj" uniqKey="Brady H">HJ Brady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name></author><author><name sortKey="Singh, K" uniqKey="Singh K">K Singh</name></author><author><name sortKey="Almasan, A" uniqKey="Almasan A">A Almasan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mah, Lj" uniqKey="Mah L">LJ Mah</name></author><author><name sortKey="El Osta, A" uniqKey="El Osta A">A El-Osta</name></author><author><name sortKey="Karagiannis, Tc" uniqKey="Karagiannis T">TC Karagiannis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tu, Wz" uniqKey="Tu W">WZ Tu</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Liu, Xd" uniqKey="Liu X">XD Liu</name></author><author><name sortKey="Guan, H" uniqKey="Guan H">H Guan</name></author><author><name sortKey="Zhang, Sm" uniqKey="Zhang S">SM Zhang</name></author><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y Tang</name></author><author><name sortKey="Rang, Wq" uniqKey="Rang W">WQ Rang</name></author><author><name sortKey="Zhou, Pk" uniqKey="Zhou P">PK Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinner, A" uniqKey="Kinner A">A Kinner</name></author><author><name sortKey="Wu, W" uniqKey="Wu W">W Wu</name></author><author><name sortKey="Staudt, C" uniqKey="Staudt C">C Staudt</name></author><author><name sortKey="Iliakis, G" uniqKey="Iliakis G">G Iliakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stoimenov, I" uniqKey="Stoimenov I">I Stoimenov</name></author><author><name sortKey="Schultz, N" uniqKey="Schultz N">N Schultz</name></author><author><name sortKey="Gottipati, P" uniqKey="Gottipati P">P Gottipati</name></author><author><name sortKey="Helleday, T" uniqKey="Helleday T">T Helleday</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Binz, Sk" uniqKey="Binz S">SK Binz</name></author><author><name sortKey="Sheehan, Am" uniqKey="Sheehan A">AM Sheehan</name></author><author><name sortKey="Wold, Ms" uniqKey="Wold M">MS Wold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sibenaller, Za" uniqKey="Sibenaller Z">ZA Sibenaller</name></author><author><name sortKey="Sorensen, Br" uniqKey="Sorensen B">BR Sorensen</name></author><author><name sortKey="Wold, Ms" uniqKey="Wold M">MS Wold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sleeth, Km" uniqKey="Sleeth K">KM Sleeth</name></author><author><name sortKey="Sorensen, Cs" uniqKey="Sorensen C">CS Sorensen</name></author><author><name sortKey="Issaeva, N" uniqKey="Issaeva N">N Issaeva</name></author><author><name sortKey="Dziegielewski, J" uniqKey="Dziegielewski J">J Dziegielewski</name></author><author><name sortKey="Bartek, J" uniqKey="Bartek J">J Bartek</name></author><author><name sortKey="Helleday, T" uniqKey="Helleday T">T Helleday</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marechal, A" uniqKey="Marechal A">A Marechal</name></author><author><name sortKey="Zou, L" uniqKey="Zou L">L Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Polo, Se" uniqKey="Polo S">SE Polo</name></author><author><name sortKey="Jackson, Sp" uniqKey="Jackson S">SP Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bach, S" uniqKey="Bach S">S Bach</name></author><author><name sortKey="Knockaert, M" uniqKey="Knockaert M">M Knockaert</name></author><author><name sortKey="Reinhardt, J" uniqKey="Reinhardt J">J Reinhardt</name></author><author><name sortKey="Lozach, O" uniqKey="Lozach O">O Lozach</name></author><author><name sortKey="Schmitt, S" uniqKey="Schmitt S">S Schmitt</name></author><author><name sortKey="Baratte, B" uniqKey="Baratte B">B Baratte</name></author><author><name sortKey="Koken, M" uniqKey="Koken M">M Koken</name></author><author><name sortKey="Coburn, Sp" uniqKey="Coburn S">SP Coburn</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L Tang</name></author><author><name sortKey="Jiang, T" uniqKey="Jiang T">T Jiang</name></author><author><name sortKey="Liang, Dc" uniqKey="Liang D">DC Liang</name></author><author><name sortKey="Galons, H" uniqKey="Galons H">H Galons</name></author><author><name sortKey="Dierick, Jf" uniqKey="Dierick J">JF Dierick</name></author><author><name sortKey="Pinna, La" uniqKey="Pinna L">LA Pinna</name></author><author><name sortKey="Meggio, F" uniqKey="Meggio F">F Meggio</name></author><author><name sortKey="Totzke, F" uniqKey="Totzke F">F Totzke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Ar" uniqKey="Tan A">AR Tan</name></author><author><name sortKey="Swain, Sm" uniqKey="Swain S">SM Swain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Ar" uniqKey="Tan A">AR Tan</name></author><author><name sortKey="Headlee, D" uniqKey="Headlee D">D Headlee</name></author><author><name sortKey="Messmann, R" uniqKey="Messmann R">R Messmann</name></author><author><name sortKey="Sausville, Ea" uniqKey="Sausville E">EA Sausville</name></author><author><name sortKey="Arbuck, Sg" uniqKey="Arbuck S">SG Arbuck</name></author><author><name sortKey="Murgo, Aj" uniqKey="Murgo A">AJ Murgo</name></author><author><name sortKey="Melillo, G" uniqKey="Melillo G">G Melillo</name></author><author><name sortKey="Zhai, S" uniqKey="Zhai S">S Zhai</name></author><author><name sortKey="Figg, Wd" uniqKey="Figg W">WD Figg</name></author><author><name sortKey="Swain, Sm" uniqKey="Swain S">SM Swain</name></author><author><name sortKey="Senderowicz, Am" uniqKey="Senderowicz A">AM Senderowicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, R" uniqKey="Lin R">R Lin</name></author><author><name sortKey="Connolly, Pj" uniqKey="Connolly P">PJ Connolly</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S Huang</name></author><author><name sortKey="Wetter, Sk" uniqKey="Wetter S">SK Wetter</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Murray, Wv" uniqKey="Murray W">WV Murray</name></author><author><name sortKey="Emanuel, Sl" uniqKey="Emanuel S">SL Emanuel</name></author><author><name sortKey="Gruninger, Rh" uniqKey="Gruninger R">RH Gruninger</name></author><author><name sortKey="Fuentes Pesquera, Ar" uniqKey="Fuentes Pesquera A">AR Fuentes-Pesquera</name></author><author><name sortKey="Rugg, Ca" uniqKey="Rugg C">CA Rugg</name></author><author><name sortKey="Middleton, Sa" uniqKey="Middleton S">SA Middleton</name></author><author><name sortKey="Jolliffe, Lk" uniqKey="Jolliffe L">LK Jolliffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franco, J" uniqKey="Franco J">J Franco</name></author><author><name sortKey="Witkiewicz, Ak" uniqKey="Witkiewicz A">AK Witkiewicz</name></author><author><name sortKey="Knudsen, Es" uniqKey="Knudsen E">ES Knudsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sano, T" uniqKey="Sano T">T Sano</name></author><author><name sortKey="Oyama, T" uniqKey="Oyama T">T Oyama</name></author><author><name sortKey="Kashiwabara, K" uniqKey="Kashiwabara K">K Kashiwabara</name></author><author><name sortKey="Fukuda, T" uniqKey="Fukuda T">T Fukuda</name></author><author><name sortKey="Nakajima, T" uniqKey="Nakajima T">T Nakajima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Helleday, T" uniqKey="Helleday T">T Helleday</name></author><author><name sortKey="Petermann, E" uniqKey="Petermann E">E Petermann</name></author><author><name sortKey="Lundin, C" uniqKey="Lundin C">C Lundin</name></author><author><name sortKey="Hodgson, B" uniqKey="Hodgson B">B Hodgson</name></author><author><name sortKey="Sharma, Ra" uniqKey="Sharma R">RA Sharma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nair, Bc" uniqKey="Nair B">BC Nair</name></author><author><name sortKey="Vallabhaneni, S" uniqKey="Vallabhaneni S">S Vallabhaneni</name></author><author><name sortKey="Tekmal, Rr" uniqKey="Tekmal R">RR Tekmal</name></author><author><name sortKey="Vadlamudi, Rk" uniqKey="Vadlamudi R">RK Vadlamudi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alessi, F" uniqKey="Alessi F">F Alessi</name></author><author><name sortKey="Quarta, S" uniqKey="Quarta S">S Quarta</name></author><author><name sortKey="Savio, M" uniqKey="Savio M">M Savio</name></author><author><name sortKey="Riva, F" uniqKey="Riva F">F Riva</name></author><author><name sortKey="Rossi, L" uniqKey="Rossi L">L Rossi</name></author><author><name sortKey="Stivala, La" uniqKey="Stivala L">LA Stivala</name></author><author><name sortKey="Scovassi, Ai" uniqKey="Scovassi A">AI Scovassi</name></author><author><name sortKey="Meijer, L" uniqKey="Meijer L">L Meijer</name></author><author><name sortKey="Prosperi, E" uniqKey="Prosperi E">E Prosperi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wojciechowski, J" uniqKey="Wojciechowski J">J Wojciechowski</name></author><author><name sortKey="Horky, M" uniqKey="Horky M">M Horky</name></author><author><name sortKey="Gueorguieva, M" uniqKey="Gueorguieva M">M Gueorguieva</name></author><author><name sortKey="Wesierska Gadek, J" uniqKey="Wesierska Gadek J">J Wesierska-Gadek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hahntow, In" uniqKey="Hahntow I">IN Hahntow</name></author><author><name sortKey="Schneller, F" uniqKey="Schneller F">F Schneller</name></author><author><name sortKey="Oelsner, M" uniqKey="Oelsner M">M Oelsner</name></author><author><name sortKey="Weick, K" uniqKey="Weick K">K Weick</name></author><author><name sortKey="Ringshausen, I" uniqKey="Ringshausen I">I Ringshausen</name></author><author><name sortKey="Fend, F" uniqKey="Fend F">F Fend</name></author><author><name sortKey="Peschel, C" uniqKey="Peschel C">C Peschel</name></author><author><name sortKey="Decker, T" uniqKey="Decker T">T Decker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mgbonyebi, Op" uniqKey="Mgbonyebi O">OP Mgbonyebi</name></author><author><name sortKey="Russo, J" uniqKey="Russo J">J Russo</name></author><author><name sortKey="Russo, Ih" uniqKey="Russo I">IH Russo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Misra, K" uniqKey="Misra K">K Misra</name></author><author><name sortKey="Paul, S" uniqKey="Paul S">S Paul</name></author><author><name sortKey="Kundu, R" uniqKey="Kundu R">R Kundu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kastan, Mb" uniqKey="Kastan M">MB Kastan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martins, Cp" uniqKey="Martins C">CP Martins</name></author><author><name sortKey="Brown Swigart, L" uniqKey="Brown Swigart L">L Brown-Swigart</name></author><author><name sortKey="Evan, Gi" uniqKey="Evan G">GI Evan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ventura, A" uniqKey="Ventura A">A Ventura</name></author><author><name sortKey="Kirsch, Dg" uniqKey="Kirsch D">DG Kirsch</name></author><author><name sortKey="Mclaughlin, Me" uniqKey="Mclaughlin M">ME McLaughlin</name></author><author><name sortKey="Tuveson, Da" uniqKey="Tuveson D">DA Tuveson</name></author><author><name sortKey="Grimm, J" uniqKey="Grimm J">J Grimm</name></author><author><name sortKey="Lintault, L" uniqKey="Lintault L">L Lintault</name></author><author><name sortKey="Newman, J" uniqKey="Newman J">J Newman</name></author><author><name sortKey="Reczek, Ee" uniqKey="Reczek E">EE Reczek</name></author><author><name sortKey="Weissleder, R" uniqKey="Weissleder R">R Weissleder</name></author><author><name sortKey="Jacks, T" uniqKey="Jacks T">T Jacks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xue, W" uniqKey="Xue W">W Xue</name></author><author><name sortKey="Zender, L" uniqKey="Zender L">L Zender</name></author><author><name sortKey="Miething, C" uniqKey="Miething C">C Miething</name></author><author><name sortKey="Dickins, Ra" uniqKey="Dickins R">RA Dickins</name></author><author><name sortKey="Hernando, E" uniqKey="Hernando E">E Hernando</name></author><author><name sortKey="Krizhanovsky, V" uniqKey="Krizhanovsky V">V Krizhanovsky</name></author><author><name sortKey="Cordon Cardo, C" uniqKey="Cordon Cardo C">C Cordon-Cardo</name></author><author><name sortKey="Lowe, Sw" uniqKey="Lowe S">SW Lowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hietanen, S" uniqKey="Hietanen S">S Hietanen</name></author><author><name sortKey="Lain, S" uniqKey="Lain S">S Lain</name></author><author><name sortKey="Krausz, E" uniqKey="Krausz E">E Krausz</name></author><author><name sortKey="Blattner, C" uniqKey="Blattner C">C Blattner</name></author><author><name sortKey="Lane, Dp" uniqKey="Lane D">DP Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kochetkov, Dv" uniqKey="Kochetkov D">DV Kochetkov</name></author><author><name sortKey="Il Inskaia, Gv" uniqKey="Il Inskaia G">GV Il'inskaia</name></author><author><name sortKey="Komarov, Pg" uniqKey="Komarov P">PG Komarov</name></author><author><name sortKey="Strom, E" uniqKey="Strom E">E Strom</name></author><author><name sortKey="Agapova, Ls" uniqKey="Agapova L">LS Agapova</name></author><author><name sortKey="Ivanov, Av" uniqKey="Ivanov A">AV Ivanov</name></author><author><name sortKey="Budanov, Av" uniqKey="Budanov A">AV Budanov</name></author><author><name sortKey="Frolova, Ei" uniqKey="Frolova E">EI Frolova</name></author><author><name sortKey="Chumakov, Pm" uniqKey="Chumakov P">PM Chumakov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dymalla, S" uniqKey="Dymalla S">S Dymalla</name></author><author><name sortKey="Scheffner, M" uniqKey="Scheffner M">M Scheffner</name></author><author><name sortKey="Weber, E" uniqKey="Weber E">E Weber</name></author><author><name sortKey="Sehr, P" uniqKey="Sehr P">P Sehr</name></author><author><name sortKey="Lohrey, C" uniqKey="Lohrey C">C Lohrey</name></author><author><name sortKey="Hoppe Seyler, F" uniqKey="Hoppe Seyler F">F Hoppe-Seyler</name></author><author><name sortKey="Hoppe Seyler, K" uniqKey="Hoppe Seyler K">K Hoppe-Seyler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Issaeva, N" uniqKey="Issaeva N">N Issaeva</name></author><author><name sortKey="Bozko, P" uniqKey="Bozko P">P Bozko</name></author><author><name sortKey="Enge, M" uniqKey="Enge M">M Enge</name></author><author><name sortKey="Protopopova, M" uniqKey="Protopopova M">M Protopopova</name></author><author><name sortKey="Verhoef, Lg" uniqKey="Verhoef L">LG Verhoef</name></author><author><name sortKey="Masucci, M" uniqKey="Masucci M">M Masucci</name></author><author><name sortKey="Pramanik, A" uniqKey="Pramanik A">A Pramanik</name></author><author><name sortKey="Selivanova, G" uniqKey="Selivanova G">G Selivanova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Cy" uniqKey="Zhao C">CY Zhao</name></author><author><name sortKey="Szekely, L" uniqKey="Szekely L">L Szekely</name></author><author><name sortKey="Bao, W" uniqKey="Bao W">W Bao</name></author><author><name sortKey="Selivanova, G" uniqKey="Selivanova G">G Selivanova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gubanova, E" uniqKey="Gubanova E">E Gubanova</name></author><author><name sortKey="Issaeva, N" uniqKey="Issaeva N">N Issaeva</name></author><author><name sortKey="Gokturk, C" uniqKey="Gokturk C">C Gokturk</name></author><author><name sortKey="Djureinovic, T" uniqKey="Djureinovic T">T Djureinovic</name></author><author><name sortKey="Helleday, T" uniqKey="Helleday T">T Helleday</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gubanova, E" uniqKey="Gubanova E">E Gubanova</name></author><author><name sortKey="Brown, B" uniqKey="Brown B">B Brown</name></author><author><name sortKey="Ivanov, Sv" uniqKey="Ivanov S">SV Ivanov</name></author><author><name sortKey="Helleday, T" uniqKey="Helleday T">T Helleday</name></author><author><name sortKey="Mills, Gb" uniqKey="Mills G">GB Mills</name></author><author><name sortKey="Yarbrough, Wg" uniqKey="Yarbrough W">WG Yarbrough</name></author><author><name sortKey="Issaeva, N" uniqKey="Issaeva N">N Issaeva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Issaeva, N" uniqKey="Issaeva N">N Issaeva</name></author><author><name sortKey="Thomas, Hd" uniqKey="Thomas H">HD Thomas</name></author><author><name sortKey="Djureinovic, T" uniqKey="Djureinovic T">T Djureinovic</name></author><author><name sortKey="Jaspers, Je" uniqKey="Jaspers J">JE Jaspers</name></author><author><name sortKey="Stoimenov, I" uniqKey="Stoimenov I">I Stoimenov</name></author><author><name sortKey="Kyle, S" uniqKey="Kyle S">S Kyle</name></author><author><name sortKey="Pedley, N" uniqKey="Pedley N">N Pedley</name></author><author><name sortKey="Gottipati, P" uniqKey="Gottipati P">P Gottipati</name></author><author><name sortKey="Zur, R" uniqKey="Zur R">R Zur</name></author><author><name sortKey="Sleeth, K" uniqKey="Sleeth K">K Sleeth</name></author><author><name sortKey="Chatzakos, V" uniqKey="Chatzakos V">V Chatzakos</name></author><author><name sortKey="Mulligan, Ea" uniqKey="Mulligan E">EA Mulligan</name></author><author><name sortKey="Lundin, C" uniqKey="Lundin C">C Lundin</name></author><author><name sortKey="Gubanova, E" uniqKey="Gubanova E">E Gubanova</name></author><author><name sortKey="Kersbergen, A" uniqKey="Kersbergen A">A Kersbergen</name></author><author><name sortKey="Harris, Al" uniqKey="Harris A">AL Harris</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Gary, Cyril" sort="Gary, Cyril" uniqKey="Gary C" first="Cyril" last="Gary">Cyril Gary</name></region><name sortKey="Bellinger, Gary" sort="Bellinger, Gary" uniqKey="Bellinger G" first="Gary" last="Bellinger">Gary Bellinger</name><name sortKey="Biktasova, Asel" sort="Biktasova, Asel" uniqKey="Biktasova A" first="Asel" last="Biktasova">Asel Biktasova</name><name sortKey="Hajek, Michael" sort="Hajek, Michael" uniqKey="Hajek M" first="Michael" last="Hajek">Michael Hajek</name><name sortKey="Issaeva, Natalia" sort="Issaeva, Natalia" uniqKey="Issaeva N" first="Natalia" last="Issaeva">Natalia Issaeva</name><name sortKey="Issaeva, Natalia" sort="Issaeva, Natalia" uniqKey="Issaeva N" first="Natalia" last="Issaeva">Natalia Issaeva</name><name sortKey="Yarbrough, Wendell G" sort="Yarbrough, Wendell G" uniqKey="Yarbrough W" first="Wendell G." last="Yarbrough">Wendell G. Yarbrough</name><name sortKey="Yarbrough, Wendell G" sort="Yarbrough, Wendell G" uniqKey="Yarbrough W" first="Wendell G." last="Yarbrough">Wendell G. Yarbrough</name><name sortKey="Yarbrough, Wendell G" sort="Yarbrough, Wendell G" uniqKey="Yarbrough W" first="Wendell G." last="Yarbrough">Wendell G. Yarbrough</name></country><country name="Australie"><noRegion><name sortKey="Biktasova, Asel" sort="Biktasova, Asel" uniqKey="Biktasova A" first="Asel" last="Biktasova">Asel Biktasova</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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